Review Article
Abstract
Diabetes mellitus (DM) remains a significant
global health challenge, causing considerable mortality and morbidity annually.
Type 2 DM is the most prevalent form of the disease, and fixed-dose
combinations of oral anti-diabetic drugs are essential for its management. This
creates a substantial demand for analytical methods capable of handling the
diverse matrices, compounds, and physicochemical complexities involved in the
quantitative analysis of these drug combinations. This article reviews current
analytical methods for the quantitative determination of metformin combined
with thiazolidinediones in various marketed formulations. The review covered
the period from 2005 to the present. The most commonly used methods include high-performance
liquid chromatography (HPLC), spectrophotometric techniques, high-performance
thin-layer chromatography (HPTLC), and capillary zone electrophoresis (CZE).
Recent trends indicate a preference for HPLC (44.8%) due to its higher
sensitivity, resolution potential, reduced sample and reagent consumption, and
shorter analysis times. This shift underscores the industry's move towards more
efficient and precise analytical techniques.
Keywords
Analysis, combination, metformin, review,
thiazolidinediones, dosage form.
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This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Abstract
Diabetes mellitus (DM) remains a significant
global health challenge, causing considerable mortality and morbidity annually.
Type 2 DM is the most prevalent form of the disease, and fixed-dose
combinations of oral anti-diabetic drugs are essential for its management. This
creates a substantial demand for analytical methods capable of handling the
diverse matrices, compounds, and physicochemical complexities involved in the
quantitative analysis of these drug combinations. This article reviews current
analytical methods for the quantitative determination of metformin combined
with thiazolidinediones in various marketed formulations. The review covered
the period from 2005 to the present. The most commonly used methods include high-performance
liquid chromatography (HPLC), spectrophotometric techniques, high-performance
thin-layer chromatography (HPTLC), and capillary zone electrophoresis (CZE).
Recent trends indicate a preference for HPLC (44.8%) due to its higher
sensitivity, resolution potential, reduced sample and reagent consumption, and
shorter analysis times. This shift underscores the industry's move towards more
efficient and precise analytical techniques.
Abstract Keywords
Analysis, combination, metformin, review,
thiazolidinediones, dosage form.
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Editor-in-Chief
This work is licensed under the
Creative Commons Attribution 4.0
License.(CC BY-NC 4.0).