Research Article
Abstract
Telmisartan is indicated for treating patients with
high blood pressure (Hypertension). This study attempted to investigate the In-vitro quality control testing of six prominent
pharmaceutical brands of Telmisartan tablets marketed in Andhra Pradesh, India.
Six different brands of tablets used in the study, named brand A (Telismart
40 mg), brand B (Telmisafe TM-40 mg),
brand C (Teltan-40 mg), brand D
(Telkonol-40 mg), brand E (Telmiwock-40
mg), and brand F (Telmikind-40), were evaluated for weight variation,
content uniformity, thickness, disintegration, hardness, friability, and Assay.
The study utilised standardised testing methods to ensure consistency and
reliability across all assessments. The results revealed that all the brands of
Telmisartan tablets complied with the official specifications for hardness,
friability, disintegration, and assay. All the selected brands of Telmisartan
tablets complied demonstrated robust mechanical strength, minimal friability,
and prompt disintegration of active pharmaceutical ingredients.
Keywords
Disintegration, drug quality, drug release, friability, hardness, thickness, telmisartan tablets.
References
1.
https://go.drugbank.com/drugs/DB00966
(accessed on 16th November,2024).
2.
Indian
pharmacopeia 2022. Volume III, Indian Pharmacopoeia Commission, Government of
India. 3726
3.
https://en.wikipedia.org/wiki/Telmisartan
(accessed on 16th November,2024).
4.
Dhiman, Vishal; Jain,
Gaurav; Jagtap, Vaibhav; Sheorey, R. V. Formulation and In-Vitro evaluation of fast dissolving tablets of
telmisartan.International Journal of Pharmacy & Life Sciences, 2012;
3(11):2159
5.
Jayendra Singh Bayasa,
Rameshwar Chekeb, Prachi Lokhandec, Santosh Waghmare d, Shivshankar
Gunjegaonkare, Sachin Shindef. In-vitro studies and evaluation of
telmisartan-marketed tablets.Journal of Drug Delivery & Therapeutics. 2019;
9(1):74-78. http://dx.doi.org/10.22270/jddt.v9i1.2267.
6.
Kapil Chauhan, Bharat
Parashar, Abhishek Chandel and Varun Thakur. Formulation and Evaluation of
fast-dissolving tablets of telmisartan. International Journal of Pharmaceutical
sciences and Research 2013; Vol. 4(4): 1514-1520.
7.
Yasser, M., Teaima, M.,
El-Nabarawi, M., & El-Monem, R. A. (2019). Cubosomal based oral tablet for
controlled drug delivery of telmisartan: formulation, in-vitro evaluation and
in-vivo comparative pharmacokinetic study in rabbits. Drug Development and
Industrial Pharmacy, 45(6), 981–994.
https://doi.org/10.1080/03639045.2019.1590392.
8.
Monica RP Rao, Rewathi
Shileda , Manjiri Bhosale, Mayuresh Garud, Ganesh Medhekar. Comparative
Dissolution Studies of Marketed Tablets of Telmisartan in Biorelevant Media.
American Journal of Pharmtech Research. 2012; 2(2):655-662.
9.
Nofar Torika, Keren
Asraf, Abraham Danon, Ron N. Apte, Sigal Fleisher-Berkovich. Telmisartan
Modulates Glial Activation: In Vitro and In Vivo Studies. Journal of PLOS One. 2016 May 17;11(5): e0155823
collection 2016. https://doi.org/10.1371/journal.pone.0155823.
10. Teaima
M, Abdelmonem R, Adel YA, El-Nabarawi MA, El-Nawawy TM. Transdermal Delivery of
Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement
and Comparative Pharmacokinetic Study in Rats. Drug Des Devel Ther.
2021;15:4603-4614. https://doi.org/10.2147/DDDT.S327860
11. Indian pharmacopeia 2022. Volume I, Indian Pharmacopoeia
Commission, Government of India.1065.
12. Indian pharmacopeia 2022. Volume I, Indian
Pharmacopoeia Commission, Government of India. Pg. No. 1146
13. Manish Kumar,
Chinmoy Kumar, Shailendra Bhatt, A. Pandurangan, Vichitra Kaushik, Anuj Malik
and Vipin Saini. Dissolution Method Development and
Validation for Tablet Dosage Form of Telmisartan Using UV Spectrophotometric
Method. Journal of chemical and pharmaceutical research. 2018;10(5): 148-156
14. Indian pharmacopeia 2022. Volume I, Indian
Pharmacopoeia Commission, Government of India.362.
15. Indian pharmacopeia 2022. Volume I, Indian
Pharmacopoeia Commission, Government of India. 351-352
16. Manish Kumar, Chinmoy Kumar, Shailendra Bhatt, A.
Pandurangan, Vichitra Kaushik, Anuj Malik and Vipin Saini. Dissolution
Method Development and Validation for Tablet Dosage Form of Telmisartan Using
UV Spectrophotometric Method. Journal of chemical and pharmaceutical research.
2018;10(5): 148-156.
17. https://www.pharmtech.com/view/measuring-tablet-hardness-primer11.
18. United States Pharmacopoeia 2000. USP24, NF19 Asian
edition, The Board of Trustees. Pg. No: 2188 and 2147.
19. https://pharmaeducation.net/quality-control-tests-of-tablets-or-evaluation-of-tablets/#google_vignette
(accessed on 16th November,2024).
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Abstract
Telmisartan is indicated for treating patients with
high blood pressure (Hypertension). This study attempted to investigate the In-vitro quality control testing of six prominent
pharmaceutical brands of Telmisartan tablets marketed in Andhra Pradesh, India.
Six different brands of tablets used in the study, named brand A (Telismart
40 mg), brand B (Telmisafe TM-40 mg),
brand C (Teltan-40 mg), brand D
(Telkonol-40 mg), brand E (Telmiwock-40
mg), and brand F (Telmikind-40), were evaluated for weight variation,
content uniformity, thickness, disintegration, hardness, friability, and Assay.
The study utilised standardised testing methods to ensure consistency and
reliability across all assessments. The results revealed that all the brands of
Telmisartan tablets complied with the official specifications for hardness,
friability, disintegration, and assay. All the selected brands of Telmisartan
tablets complied demonstrated robust mechanical strength, minimal friability,
and prompt disintegration of active pharmaceutical ingredients.
Abstract Keywords
Disintegration, drug quality, drug release, friability, hardness, thickness, telmisartan tablets.
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Editor-in-Chief
This work is licensed under the
Creative Commons Attribution 4.0
License.(CC BY-NC 4.0).