Research Article
Francis Chukwuedozie Nwachukwu*
Francis Chukwuedozie Nwachukwu*
Corresponding Author
Nigeria Police Academy, Department of Biochemistry and Forensic Science, Faculty of Science, P. M B 3474, Wudil, Kano State, Nigeria.
E-mail: nwachukwuchukwuedozie@gmail.com, tilong3788@yahoo.com
Tel: +2347064664777
Received: 2024-12-18 | Revised:2025-07-06 | Accepted: 2025-07-08 | Published: 2025-09-25
Pages: 113-123
DOI: https://doi.org/10.58985/jpam.2025.v03i02.38
Abstract
Many promoting factors of cardiometabolic disease are commonplace in Police Academy (POLAC), such as prolonged sitting, forgoing sleep, poor stress management, and others. The research aimed to establish the cardiometabolic profile of some POLAC staff. Voluntary staff members participated in the study. The participants fasted for at least ten hours. Plasma capillary blood parameters (glucose, haemoglobin, and total cholesterol), blood pressure (BP) and anthropometry (waist and hip circumference, and height and weight) were determined. The Body mass index (BMI) and waist-to-hip circumference ratios were calculated using the appropriate formula. The participants were divided into five groups according to age range (Group1 = 40-45, Group2 = 46-50, Group3 = 51-55, Group4 = 56-60, and Group5 = 61-65). The results showed the presence of high glucose concentrations (glucose > 6.8mmol/L) in all groups, high haemoglobin concentrations (haemoglobin > 17.2g/dl) in two groups (1 and 2), high total cholesterol concentrations (total cholesterol > 240 mg/dl) in four groups (1, 2, 3, and 5), and high BMI (BMI > 24.9 kg/m2), high BP (BP ≥ 140/90 mmHg) and high waist-to-hip ratio (values > 1) in all groups. The mean glucose, BP and anthropometric measurements were elevated across all groups. Individually, there were no significant differences among the groups. High glucose concentrations, BP and anthropometric values in all groups reflect that glucose concentration impacts body anthropometry alongside BP and anthropometry reflect glucose status. The high total cholesterol concentrations in the four groups rather than all groups showed glucose may trigger an increase in total cholesterol, and other factors may be involved. Haemoglobin concentration is less affected by glucose concentration. Changes in these parameters reflect cardiometabolic health conditions.
Keywords
Cardiometabilic condition, anthropometrics, glucose, haemoglobin and cholesterol.
1. Introduction
Cardiometabolic syndrome is a state in which multiple risk factors are present simultaneously rather than individually [1]. It describes a cluster of metabolic and cardiovascular abnormalities, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and atherosclerosis which cause cardiovascular disease (CVD) and diabetes. This constellation of many risk factors under the umbrella of the term- cardiometabolic health may be associated with one another [2], although not in all situations. It can occur in isolation or independently of others. The biochemical basis of disease is the focus of a good understanding of cardiometabolic health conditions. According to Nwachukwu [3], all diseases have a biochemical basis, and cardiometabolic health follows the same biochemical basis. Considering that changes in biochemical parameters can reflect cardiometabolic health, biochemical indicators of syndromes in cardiometabolic health have become screening tools. The constellation of risk factors negatively impacts the synergy of metabolic processes in the body.
The ability to process food that maintains blood sugar, cholesterol, triacylglycerol, blood pressure, and body weight within a healthy range for optimal metabolism provides a profile of cardiometabolic health. Cardiometabolic health reflects internal processes regulated by a homeostatic system. Indisputably, more than 30% of the global population is either obese or overweight [4], and the leading cause of death worldwide is cardiovascular disease [5-6]. To reduce the risk of developing cardiometabolic diseases, public health interventions have traditionally focused on increasing physical activity, improving diet quality, and reducing tobacco use and alcohol intake [7]. There was less progress in physical activity and healthy dietary habits. These lifestyle factors are notoriously difficult to modify [8]. Dietary habits influence the risk factors for cardiometabolic health [9-10]. Furthermore, there is compelling evidence that engaging in 30–60 min of moderate-vigorous intensity physical activity daily improves health and reduces the prevalence of chronic disease [11-13].
The prevalence of cardiometabolic diseases has been increasing recently [14-15], especially in high and middle-income countries [15]. Many working-class individuals engage in unhealthy behaviours such as forgoing sleep, and making poor food choices, etc., and this is an increasingly globally prevalent issue [16]. The reasons for an unhealthy lifestyle are multifactorial, including work, society, family, and others. An unhealthy lifestyle triggers increased stress, cancer, cardiovascular disease, type 2 diabetes, and other conditions culminating in reduced life expectancy and increased mortality rate (Fig 1). An unhealthy lifestyle impacts health through independent, culminative and combined effects. Notably, unhealthy lifestyles could be interrelated [17].
Figure 1. Unhealthy behaviour and linked degenerative processes.
An unhealthy lifestyle affects cardiometabolic health because many of the diseases triggered by unhealthy lifestyles fall under the umbrella term cardiometabolic diseases. As such, investigations inform interventions to prevent the development of cardiometabolic diseases [18]. Cardiometabolic screening is a step in the development of an informed and strategic intervention plan for improving health and life expectancy.
In the Nigeria Police Academy (POLAC), about nine staff died within ten years, and in each case, it was not an accident. This troubling information is suspected to have originated from cardiometabolic episodes. The cardiometabolic screening could lead to interventions that could scale down cardiometabolic risk factors, cardiometabolic disease development, and reduction of cardiometabolic-related death. The POLAC authority (management authorities) may take clues from this research, which is the expected significance of the current study. The findings will propel these significances, and the aim is to screen the selected POLAC staff for markers of cardiometabolic health.
2. Materials and methods
2.1. Materials
The materials used in this study were intended for on-the-spot assessments. These included the Accu-Answer Isaw (CEO197) and its kits (China), a lancing device, methanol, a portable electronic balance, sphygmomanometer, measuring tape, and standiometer, all sourced from Chriscare Medical Devices Nigeria Limited, as an accredited distributor of medical devices.
2.2. Participants of the health screening component of this observational study
The participants were males and females over 40 years of age. They provided oral consent after a one-on-one counselling session. All participants were voluntary volunteered The confidentiality of the participants’ health information was assured. Each participant had the right to back off at any stage of the investigation. The researcher used a name code to conceal the individual’s identity. The participants were divided into five groups according to age range: Group 1 (40-45), Group 2 (46-50), Group 3 (51-55), Group 4 (56-60), and Group 5 61-65).
2.3. Exclusion and inclusion criteria
The exclusion criteria included those on medication that impacts the cardiometabolic risk factors of research interest. These include regular hypertension, diabetes drug medication, and others. The participants must have been staff members of the institution for at least four years, as the number of years spent may correlate with the length of the impact of the behaviours on their health. Inclusion criteria were those who were not on routine drug medications and were not aware of any existing cardiometabolic issues.
2.4.Study population selection
One hundred (100) POLAC staff members volunteered to participate in the study. Seven (7) Participants were below 30 years of age. Nine (9) participants withdrew on personal grounds, and fifteen (15) were disallowed due to existing ill-health. This resulted in thirty-two (32) participants’ exclusion. The remaining sixty-three (68) were included in the final study.
2.5.Anthropometric estimation and blood pressure check
The reference ranges were as per Aminu Kano Teaching Hospital (BMI > 24.9 kg/m2), high blood pressure (blood pressure ≥ 140/90) and high waist-to-hip ratio (values > 1).
2.6. Height measurement
The participant was in an erect standing position on the floorboard of the standiometer, with their back vertically aligned with the backboard of the standiometer. For an even distribution of the participant's weight, the heels of the feet were placed together and made to touch the vertical board base. The feet were slightly outward at an angle of 60 degrees. For participants with knocked knees, the feet were in a separate position so that the inside of the knees were in contact but not overlapping. In this position, the head and buttocks were in contact with the vertical backboard. At this point, the participant's arms hung freely on the sides of the trunk, and their palms faced the thighs. The participants inhaled air deeply while standing fully without changing their heel position. In the Frankfort horizontal plane position, the examiner gently lowered the horizontal bar onto the crown of the head, applying sufficient pressure to flatten the hair. The measurement was then taken and recorded to the nearest meter. This procedure was followed for all the participants.
2.7. Weight measurement
The participants stood at the centre of the portable electronic weighing scale. While still at the centre of the electronic balance without bending the head, the reading was displayed on the portable electronic scale in kg. This procedure was done for all the participants.
2.8. Waist and hip circumference measurements
2.8.1. Waist circumference
The participants stood upright while holding up their gowns. The examiner, positioned behind the participant, palpated the hip area to locate the right iliac crest. A horizontal line was drawn at the highest point of the iliac crest, intersected by a vertical line marked on the midaxillary line of the body. The examiner then moved to the participant's right side and positioned a measuring tape horizontally around the trunk at the marked level. The recorder circled the participant to ensure that the tape was parallel to the floor and snugged without compressing the skin. The measurement was taken during minimal respiration and recorded to the nearest 0.1 cm. This procedure was for all participants.
2.8.2. Buttocks (Hip) circumference
The participants stood upright with their feet together, distributing their weight evenly on both feet while holding the examination gown. While standing behind the participant, the recorder gathered the side seams of the examination above the hips, creating a fold by inserting the thumb into the fabric. The recorder held the folded seams snugly as the examiner squatted on the participant’s right side and positioned the measuring tape around the buttocks, ensuring that it was at maximum extension. The recorder adjusted the tape at the sides and front to ensure that it lies horizontally. The zero end of the tape was below the measurement value. The tape was held snugly but not overly tight, and the examiner recorded the measurement from the right side, calling it out to the recorder. This procedure was for all participants.
Body Mass Index ( BMI) and waist – hip ratio were calculated as weight in kilograms divided by the square of height in meters
and waist divided by hip circumference in centimetres 
2.8.3. Blood pressure check
The participants were seated comfortably with their arms supported at the heart level. The cuff was wrapped snugly around the upper arm, ensuring that the artery marker was well-positioned over the brachial artery. The cuff was then inflated rapidly to a pressure of 20–30 mmHg above the point at which the radial pulse was no longer palpable, indicating complete arterial occlusion. Next, the cuff was gradually deflated while the researcher auscultated the brachial artery using a stethoscope. The first audible Korotkoff sound was recorded as the systolic pressure, indicating the resumption of blood flow through the arteries. As deflation continued, the sounds gradually faded and the point at which they disappeared marked the diastolic pressure, representing the resting phase of the cardiac cycle.
2.8.4. Participant preparations
The participants were overnight fasting for 10 ± 1 hours before blood plasma samples were tested (the testing was in the morning). The participants were not allowed to eat after 10 p.m. Testing was completed by 10 a.m. Methanol was used for finger cleaning before the lancet finger prick.
2.8.5. Operation of lancing device, meter calibration and blood sample testing
The cap of the lancet device was removed by twisting it off and inserting it into the holder, which was then pushed firmly. The protected disk was twisted until it separated from the lancet. It was recapped by twisting it back until it was snugged. The end cap of the lancet was held in one hand and the arming barrel in the other hand, then the arming barrel was gently pulled until a click was heard.
2.8.6. Finger pricking (Blood collection)
The lancing device was held firmly against the side of the finger. On this position, it was pressed to release the button, and then the lancing device was removed from the finger. The finger was gently squeezed/massaged until a round drop of blood (at least 1.5 μL) formed on the fingertip.
2.8.7. Calibration of the meter using the code number (Accu-Answer Isaw meter)
The test strip was inserted into the port to activate the meter, with the three contact bars oriented toward the operator. The test strip insertion was smooth and without bending. The meter displayed the same code on the vial. If the code did not match, the 'C' button was pressed to reset it to match the code on the test strip. The new code number would flash on the display for three seconds, then briefly stop flashing, followed by the symbol for the test parameter. It was for the indication of the meter's readiness for testing.
2.8.8. Total cholesterol, haemoglobin and fasting blood sugar testing (using accu-answer isaw)
The test strip was inserted into the calibrated meter port, which was powered on. The test strips were used for cholesterol, glucose, and hemoglobin testing. The test strip was removed from the vial and promptly inserted into the device port. The device meter displayed "CHO" for total cholesterol, "HB" for hemoglobin, and "BG" for glucose, along with the corresponding code numbers from the vials. The reference values from the Aminu Kano Teaching Hospital were used for total cholesterol, haemoglobin, and glucose concentrations. The normal ranges and values were as per the Aminu Kano Teaching Hospital reference range. (glucose > 6.8 mmol/L, haemoglobin > 17.2 g/dl and total cholesterol > 240).
2.9.Statistical analyses
Data were analyzed using SPSS 25.0 (SPSS Inc., Chicago, IL, USA). The generated data are expressed as the mean, and Post-hoc analysis was conducted at a significance level p<0.05.
3. Results
The results are presented in Tables 1 to 5 and grouped according to age range (40-45, 46-50, 51- 55, 56-60, and 61-65) as groups 1, 2, 3, 4 and 5. Table 6 presents a comparison of the mean values of the same parameters across Tables 1 to 5 for the different age ranges.
The age range of 40-45 years included 23 participants (Table 1). In plasma concentration: 15, 2, and 4 participants were higher than the reference limit concentrations for glucose, haemoglobin, and total cholesterol. In the anthropometric and blood pressure parameters, 15, 9, and 11 participants exceeded the reference limit values for body mass index, waist to hip ratio, and blood pressure, respectively. The age range 46-50 years included 14 participants (Table 2). In terms of plasma concentrations, 7, 1 and 5 participants had glucose, haemoglobin, and total cholesterol levels exceeding the reference limits, respectively. In the anthropometric and blood pressure parameters, 7, 7, and 5 participants higher than the reference limit values for body mass index, waist to hip ratio, and blood pressure, respectively. The age range 51-55 years included 14 participants (Table 3). In plasma concentration, 4 participants had higher than the reference limit concentrations for glucose, and total cholesterol, but none for haemoglobin concentration. In the anthropometric and blood pressure parameters, 4, 5 and 4 participants had values higher than the reference limit values for body mass index, waist to hip ratio, and blood pressure, respectively. The age range of 56-60 years had 7 participants (Table 4). In plasma concentration, 5 participants had higher values than the reference limit concentration for glucose and none for haemoglobin and total cholesterol concentrations. In the anthropometric and blood pressure parameters, 5, 4, and 2 participants had higher values than the reference limit values for body mass index, waist to hip, and blood pressure, respectively. The age range 61-65 had 7 participants (Table 5). In plasma concentration, 7 and 2 participants had higher values than the reference limit concentration for glucose and total cholesterol and none had higher haemoglobin concentration. In the anthropometric and blood pressure parameters, 7, 5, and 4 participants exceeded the reference limit values for body mass index, waist to hip ratio, and blood pressure, respectively. Higher-than-reference glucose concentrations and all anthropometric values, along with blood pressure values were obtained in all age ranges (Tables 1 to 5).
Table 1. Group 1 Cardiometabolic health among the Age range of 40 -45.
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (Mmo/l)
Hb (g/dl)
TC (g/dl)
BMI (kg/m2)
W:H
BLDPS (mmHg)
BLDPD (mmHg)
1
5.75
13.23
119
27.68h
1.02h
120. 05
80.50
2
7.81h
15.20
200
33.12h
0.19
145.50h
100.00h
3
5.74
15.00
300h
26.56h
1.28h
154.50h
91.50h
4
9.22 h
14.00
236
27.15h
0.70
162.50h
95.50h
5
5.28
15.00
232
22.53
1.12h
125.50
80.70
6
8.61h
12.40
224
20.99
0.72
140.00h
100.00h
7
10.02h
13.43
156
32.03h
0.65
118. 00
70.50
8
9.17h
14.40
245h
31.14h
1.45h
150.50h
98.50h
9
5.28
20.37h
173
29.30h
0.73
79.50
45.50
10
9.06h
12.50
190
24.69
0.78
120.50
72.50
11
5.56
13.43
240
31.14h
0.67
145.50h
90.50h
12
6.61
13.07
206
25.49h
0.78
147.50h
100.50h
13
10.27h
14.14
183
22.66
1.02h
127.50
80.50
14
5.67
13.23
119
27.68h
1.02h
120.50
80.50
15
7.78h
15.20
200
33.12h
0.19
147.60
80.20
16
6.94h
15.00
245h
26.56h
1.28h
150.50h
90.50h
17
10.28h
14.00
236
22.15
0.70
113. 00
70.50
18
5.28
15.00
232
22.53
1.12h
165.50h
100.50h
19
11.2h
12.41
224
20.99
0.87
160.50h
100.50h
20
9.97h
13.43
156
32.03h
0.74
110.5
71.50
21
9.72h
14.40
245h
31.14h
1.05h
153.50h
95.50h
22
9.06h
20.37h
173
29.30h
0.73
75.50
45.50
23
9.06h
12.53
190
24.69
0.78
120.50
75.50
FBS=fasting blood sugar, Hb=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W:H=waist to Hip ratio, BLDPS=blood pressure systolic and BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (Mmo/l)
Hb (g/dl)
TC (g/dl)
BMI (kg/m2)
W:H
BLDPS (mmHg)
BLDPD (mmHg)
1
5.75
13.23
119
27.68h
1.02h
120. 05
80.50
2
7.81h
15.20
200
33.12h
0.19
145.50h
100.00h
3
5.74
15.00
300h
26.56h
1.28h
154.50h
91.50h
4
9.22 h
14.00
236
27.15h
0.70
162.50h
95.50h
5
5.28
15.00
232
22.53
1.12h
125.50
80.70
6
8.61h
12.40
224
20.99
0.72
140.00h
100.00h
7
10.02h
13.43
156
32.03h
0.65
118. 00
70.50
8
9.17h
14.40
245h
31.14h
1.45h
150.50h
98.50h
9
5.28
20.37h
173
29.30h
0.73
79.50
45.50
10
9.06h
12.50
190
24.69
0.78
120.50
72.50
11
5.56
13.43
240
31.14h
0.67
145.50h
90.50h
12
6.61
13.07
206
25.49h
0.78
147.50h
100.50h
13
10.27h
14.14
183
22.66
1.02h
127.50
80.50
14
5.67
13.23
119
27.68h
1.02h
120.50
80.50
15
7.78h
15.20
200
33.12h
0.19
147.60
80.20
16
6.94h
15.00
245h
26.56h
1.28h
150.50h
90.50h
17
10.28h
14.00
236
22.15
0.70
113. 00
70.50
18
5.28
15.00
232
22.53
1.12h
165.50h
100.50h
19
11.2h
12.41
224
20.99
0.87
160.50h
100.50h
20
9.97h
13.43
156
32.03h
0.74
110.5
71.50
21
9.72h
14.40
245h
31.14h
1.05h
153.50h
95.50h
22
9.06h
20.37h
173
29.30h
0.73
75.50
45.50
23
9.06h
12.53
190
24.69
0.78
120.50
75.50
FBS=fasting blood sugar, Hb=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W:H=waist to Hip ratio, BLDPS=blood pressure systolic and BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range
Table 2. Group 2 Cardiometabolic health among the Age range of 46-50.
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (mg/dl)
Hb (g/dl)
TC (mg/dl)
BMI (kg/m2)
W:H
BLDPS (mmHg)
BLDPS (mmHg)
24
5.17
14.23
250h
32.00h
1.20h
90.50
50.50
25
5.61
13.07
296h
25.49h
0.78
145 00h
100.50h
26
10.28h
14.14
183
22.66
1.02h
125.30
83.50
27
9.28h
15.50
250h
19.99
1.00
101.50
73.50
28
7.11h
16.00
244h
23.67
1.00
155. 50h
90.00h
29
11.17h
13.37
231
21.45
0.56
168. 00h
100.00h
30
5.56
12.31
203
23.20
0.73
120.00
80.50
31
10.39h
14.11
208
22.43
0.70
135.50
85.00
32
10.83h
13.40
219
29.42h
1.03h
120.00
75.50
33
5.11
15.75
188
29.32h
1.02h
70.00
70.00
34
9.28h
18.00h
232
31.42h
1.21h
168.5h
100.00h
35
5.78
14.16
104
22.47
0.87
121.50
80.00
36
5.61
16.04
282h
31.00h
1.40h
166.00h
110.5h
37
5.50
14.43
149
29.00h
1.02h
105.50
70.50
FSB=Fasting blood sugar, Hb=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W:H=waist to Hip ratio, BLDPS=blood pressure systolic and BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (mg/dl)
Hb (g/dl)
TC (mg/dl)
BMI (kg/m2)
W:H
BLDPS (mmHg)
BLDPS (mmHg)
24
5.17
14.23
250h
32.00h
1.20h
90.50
50.50
25
5.61
13.07
296h
25.49h
0.78
145 00h
100.50h
26
10.28h
14.14
183
22.66
1.02h
125.30
83.50
27
9.28h
15.50
250h
19.99
1.00
101.50
73.50
28
7.11h
16.00
244h
23.67
1.00
155. 50h
90.00h
29
11.17h
13.37
231
21.45
0.56
168. 00h
100.00h
30
5.56
12.31
203
23.20
0.73
120.00
80.50
31
10.39h
14.11
208
22.43
0.70
135.50
85.00
32
10.83h
13.40
219
29.42h
1.03h
120.00
75.50
33
5.11
15.75
188
29.32h
1.02h
70.00
70.00
34
9.28h
18.00h
232
31.42h
1.21h
168.5h
100.00h
35
5.78
14.16
104
22.47
0.87
121.50
80.00
36
5.61
16.04
282h
31.00h
1.40h
166.00h
110.5h
37
5.50
14.43
149
29.00h
1.02h
105.50
70.50
FSB=Fasting blood sugar, Hb=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W:H=waist to Hip ratio, BLDPS=blood pressure systolic and BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range
Table 3. Group 3 Cardiometabolic health among the Age range of 51- 55.
Participant Code | Plasma biochemical parameters | Anthropometric parameters | |||||
FBS (Mmo/l) | Hb (g/dl) | TC (mg/dl) | BMI (kg/m2) | W:H | BLDPS (mmHg) | BLDPD (mmHg) | |
38 | 6.44 | 15.12 | 189 | 21.14 | 0.89 | 120.50 | 80.00 |
39 | 5.56 | 16.80 | 174 | 23.41 | 0.86 | 135.50 | 90.50 |
40 | 6.17 | 16.43 | 244h | 33.76h | 1.33h | 160.50h | 100.00h |
41 | 11.33h | 15.34 | 211 | 29.12h | 1.19h | 113.50 | 70.50 |
42 | 5.38 | 14.87 | 243h | 24.00 | 0.76 | 100.00 | 70.00 |
43 | 6.44 | 13.33 | 238 | 23.21 | 0.80 | 120.00 | 70.50 |
44 | 6.17 | 15.00 | 232 | 20.32 | 1.11h | 171.50h | 100.00h |
45 | 9.89h | 16.41 | 278h | 19.98 | 1.32h | 141.00h | 90.00h |
46 | 10.90h | 15.55 | 162 | 32.12 h | 0.78 | 120.00 | 85.00 |
47 | 5.56 | 15.23 | 117 | 23.15 | 0.76 | 112.50 | 70.50 |
48 | 6.61 | 14.11 | 195 | 22.05 | 0.88 | 100.00 | 60.00 |
49 | 11.56h | 15.23 | 243h | 21.23 | 1.09 h | 150.50h | 100. 00h |
50 | 4.89 | 14.68 | 188 | 29.31h | 0.73 | 90.00 | 60.50 |
51 | 4.51 | 15.04 | 119 | 19.41 | 0.91 | 100.00 | 70.00 |
FBS=Fasting Blood Sugar, Hb=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W:H=waist to Hip ratio, BLDPS=blood pressure systolic and BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range. | |||||||
Table 4. Group 4 Cardiometabolic health among the Age range of 56-60.
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (Mmo/l)
Hb (g/dl)
TC (mg/dl)
BMI (kg/m2)
W-H
BLDPS (mmHg)
BLDPD (mmHg)
52
6.67
12.30
118
27.68h
1.02h
120.50
80.00
53
7.56h
14.21
215
31.21h
0.16
150.50h
102.00h
54
6.94h
14.00
202
27.43h
1.21h
165. 00h
99.00h
55
9.44h
14.78
232
21.15
0.70
110.50
73.00
56
5.56
14.90
232
21.63
1.10h
135.50
90.50
57
11.11h
15.12
234
29.96h
1.04h
114.50
75.50
58
7.94h
16.00
199
29.86h
0.92
125.50
77.00
FBS=Fasting blood sugar, Hb=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W:H=waist to Hip ratio, BLDPS=blood pressure systolic and, BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (Mmo/l)
Hb (g/dl)
TC (mg/dl)
BMI (kg/m2)
W-H
BLDPS (mmHg)
BLDPD (mmHg)
52
6.67
12.30
118
27.68h
1.02h
120.50
80.00
53
7.56h
14.21
215
31.21h
0.16
150.50h
102.00h
54
6.94h
14.00
202
27.43h
1.21h
165. 00h
99.00h
55
9.44h
14.78
232
21.15
0.70
110.50
73.00
56
5.56
14.90
232
21.63
1.10h
135.50
90.50
57
11.11h
15.12
234
29.96h
1.04h
114.50
75.50
58
7.94h
16.00
199
29.86h
0.92
125.50
77.00
FBS=Fasting blood sugar, Hb=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W:H=waist to Hip ratio, BLDPS=blood pressure systolic and, BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range
Table 5. Group 5 Cardiometabolic health among the Age range of 61-65.
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (Mmo/l)
Hb (g/dl)
TC (mg/dl)
BMI (kg/m2)
W-H
BLDPS (mmhg)
BLDPD (mmhg)
59
5.67h
14.23
118
27.18h
1.03h
125.50
81.00
60
10.50h
14.54
226
23.18
0.70
155.00h
100.50h
61
7.61h
16.00
200
31.21h
0.17
135.50
94.50h
62
5.80
15.98
200
28.61h
1.05h
155.50h
100.00h
63
5.56
15.00
320h
27.30h
1.20h
161.50h
100. 00h
64
9.61h
16.00
224
24.00
0.83
135.50
90.50
65
11.33h
15.40
240h
32.41h
1.30h
140.50h
96.00h
66
5.28
13.32
173
29.40h
0.76
73.50
47.50
67
9.17h
13.65
180
23.12
0.78
120.50
70.50
68
11.38h
14.31
154
29.00h
1.26h
110.50
75.50
FBS=Fasting Blood Sugar, Ha=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W: H=waist to Hip ratio, BLDPS=blood pressure systolic and, BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range.
Participant
Code
Plasma biochemical parameters
Anthropometric parameters
FBS (Mmo/l)
Hb (g/dl)
TC (mg/dl)
BMI (kg/m2)
W-H
BLDPS (mmhg)
BLDPD (mmhg)
59
5.67h
14.23
118
27.18h
1.03h
125.50
81.00
60
10.50h
14.54
226
23.18
0.70
155.00h
100.50h
61
7.61h
16.00
200
31.21h
0.17
135.50
94.50h
62
5.80
15.98
200
28.61h
1.05h
155.50h
100.00h
63
5.56
15.00
320h
27.30h
1.20h
161.50h
100. 00h
64
9.61h
16.00
224
24.00
0.83
135.50
90.50
65
11.33h
15.40
240h
32.41h
1.30h
140.50h
96.00h
66
5.28
13.32
173
29.40h
0.76
73.50
47.50
67
9.17h
13.65
180
23.12
0.78
120.50
70.50
68
11.38h
14.31
154
29.00h
1.26h
110.50
75.50
FBS=Fasting Blood Sugar, Ha=Haemoglobin, TC=Total cholesterol, BMI=Body Mass Index, W: H=waist to Hip ratio, BLDPS=blood pressure systolic and, BLDPD=blood pressure diastolic. Numbers bearing h are above the reference range.
Table 6 shows that the mean glucose concentrations across all age groups exceeded the reference ranges. The highest and lowest mean glucose levels were 8.19 mg/dL in the 61–65 age group and 7.24 mg/dL in the 51–55 age group, respectively. The mean haemoglobin, total cholesterol, blood pressure, and body mass index (BMI) across age groups generally fell within reference limits in the study. However, only the BMI in the 51–55 age group (24.44 kg/m²) was within the normal range. The highest mean haemoglobin level was 15.22 g/dL in the 51–55 age group, while the lowest was 14.42 g/dL in the 40–46 age group. For total cholesterol, the highest mean value was 217 mg/dL in the 46–50 age group, and the lowest was 202.36 mg/dL in the 51–55 group (Table 6). Systolic blood pressure was highest (132.83 mmHg) in the 40–45 years age group and lowest (123.96 mmHg) in the 51–55 years age group. Diastolic pressure was highest (85.6 mmHg) in the 61–65 group and lowest (79.82 mmHg) in the 51–55 years age group (Table 6). For anthropometric measures, the highest BMI was 27.54 kg/m² (61–65 years age group) and the lowest was 24.44 kg/m² (51–55 years age group). The waist-to-hip ratio ranged from a high of 0.97 (46–50 years age group) to a low of 0.85 (40–46 years age group) (Table 6). Overall, there were no statistically significant differences among the age groups (P > 0.05) (Table 6).
Table 6. Comparison of the
mean plasma biochemical, anthropometric, and blood pressure parameters across
the different age ranges.
Age in years
40 -45
46-50
51- 55
56-60
61-65
FBS (mg/dl)
7.97±2.065
7.62±2.42
7.24±2.51
7.89±1.86
8.19±2.50
Ha (g/dl)
14.42±2.09
14.61±1.50
15.22±0.91
14.47±1.16
14.84±0.99
TC (mg/dl)
205.39±43.58
217.07±50.74
202.36±48.11
204.57±40.85
203.5±54.87
BMI (kg/m2)
27.16± 4.02
25.97± 4.20
24.44± 4.68
26.90±+ 4.05
27.54± 3.25
W-H
0.85±0.31
0.97± 0.22
0.96± 0.21
0.88±0.35
0.91± 0.34
BLDPS (mmHg)
132.83±24.28
128.06±30.31
123.96±24.62
131.71±19.94
131.35±26.04
BLDPD(mmHg)
83.37±16.08
83.57±15.77
79.82±14.37
85.29±11.82
85.6±17.16
No significant difference exist among the group at p>0.05.
Age in years
40 -45
46-50
51- 55
56-60
61-65
FBS (mg/dl)
7.97±2.065
7.62±2.42
7.24±2.51
7.89±1.86
8.19±2.50
Ha (g/dl)
14.42±2.09
14.61±1.50
15.22±0.91
14.47±1.16
14.84±0.99
TC (mg/dl)
205.39±43.58
217.07±50.74
202.36±48.11
204.57±40.85
203.5±54.87
BMI (kg/m2)
27.16± 4.02
25.97± 4.20
24.44± 4.68
26.90±+ 4.05
27.54± 3.25
W-H
0.85±0.31
0.97± 0.22
0.96± 0.21
0.88±0.35
0.91± 0.34
BLDPS (mmHg)
132.83±24.28
128.06±30.31
123.96±24.62
131.71±19.94
131.35±26.04
BLDPD(mmHg)
83.37±16.08
83.57±15.77
79.82±14.37
85.29±11.82
85.6±17.16
No significant difference exist among the group at p>0.05.
4. Discussion
This study screened for cardiometabolic risk factors in both males and females in the POLAC. Haemoglobin, cholesterol, glucose, blood pressure and body anthropometry are sensitive indicators for monitoring cardiometabolic syndromes and cardiometabolic health [19-20]. The participants were grouped by age range, as reported [21].
In all age ranges (Group 1 to 5), the presence of plasma high glucose concentration (concentration above reference limit) was observed, depicting the endemic nature of the high glucose concentration in the study participants (Tables 1 to 5). The mean glucose concentration was higher than the reference concentration limit in all age ranges (Table 6), making the glucose concentration the most critical parameter. By extension, it is a prevalent condition in the larger society to the larger society, [22]. Over time, participants could suffer from the consequences of high glucose concentrations, ranging from microvascular to macrovascular complications [23]. High glucose concentration predispose body proteins and lipids to glycation, distorting the features and functions of the affected macromolecules. Moreover, high glucose concentration, called hyperglycemia, induces oxidative stress and inflammation, intensifies endothelial dysfunction, vascular damage, and others [24] (Fig. 2).
Figure 2. Potential relationship between glucose and cardiometabolic conditions.
Prolonged exposure to high glucose concentrations promotes insulin resistance [25]. High glucose concentration over time reduces the effectiveness of insulin action and other factors [25]. Diabetes is a diseases associated with cardiometabolic syndrome. It is usually diagnosed in individuals above 40 years of age [26] making the selected age groups appropriate for the research. Furthermore, Insulin resistance degenerates into the failing ability to cope with metabolic necessities [27] and by projection, it was the underlying cause of many diseases in cardiometabolic conditions [28]. Insulin resistance is a window of opportunity for the development of cardiometabolic syndromes or diseases.
High cholesterol (above the reference concentration limit) is a cardiometabolic marker. It did not cut across all age ranges and was sparse within the affected age groups. Prolonged elevated cholesterol levels are a risk factor for hypertension, another condition in the constellation of cardiometabolic conditions [29]. Aside from hypertension, persistent high cholesterol levels trigger for many sequels in cardiometabolic syndrome [30]. The mean cholesterol concentration among the age range was not above the reference limit, showing that high cholesterol is less of a problem in the selected participants. It is important to note that cholesterol plays a lesser role as a contributing factor to the cardiometabolic syndrome observed in the groups. The haemoglobin concentrations were within the reference limit in most of the age ranges, and the mean haemoglobin level was within the reference range, making it an insignificant contributor to cardiometabolic syndrome.
Among the anthropometric parameters checked (waist-to-hip ratio, and body mass index) the blood pressure values which were higher than the reference limit in all the groups (Table 1to 5), making them a contributing factor to the condition of hypertension. The presence of higher-than-reference values in all age groups may be a consequence of the combined presence of high glucose and cholesterol concentrations in the groups investigated. High blood pressure is a risk factor for hypertension (increased systolic and diastolic pressure), regardless of the glucose level [31]. Hypertension is among the constellation of symptoms that make up the cardiometabolic syndrome. A possible cause of distorted biochemical and accompanying anthropometry (total cholesterol, BMI, and others) was a high glucose concentration (Tables 1 to 5). [32]. High glucose concentration triggers an increase in cholesterol levels, which might lead to the development of atherosclerotic plaques [33] and poor anthropometric status among participants. Metabolic health remained consistent across the various age categories, as evidenced by the lack of statistically significant differences, indicating a uniform pattern in the measured parameters across age ranges.
5. Conclusions
The cardiometabolic risks were found to be present in the study participants, and there was no difference in metabolic syndrome across the age groups. High glucose off-limit concentrations likely triggered other parameters to the concentrations above their reference limits. Glucose concentration was the major contributor to cardiometabolic disease among the participants.
Considering the findings of this study, periodic glucose screening and blood pressure measurements are needed among the POLAC community. It is advisable at the individual level. Again, it is recommended that a comprehensive lipid profile with sex categorization and additional diabeties marker assessments be conducted.
Ethical Statement
This research was in line with the Nigeria Police Academy ethical standards on the use of humans for research purposes. The project output of the research was deposited in the Department of Biochemistry and Forensic Science and received departmental approval following submission to the Department of Biochemistry and Forensic Science of the Nigeria Police Academy.
Disclaimer (artificial intelligence)
Author(s) hereby state that no generative AI tools such as Large Language Models (ChatGPT, Copilot, etc.) and text-to-image generators were utilized in the preparation or editing of this manuscript.
Authors’ contributions
It is not applicable because a single author constructed this manuscript.
Acknowledgements
The researcher is grateful to members of Police Academy Staff and community and my students who assisted me during the bench work.
Funding
This research received no external funding.
Availability of data and materials
All relevant data are within the paper. Additional data will be made and available on request according to the journal policy.
Conflicts of interest
The author declares and confirms that there are no known conflicts of interest, no known competing financial interests, or personal relationships that could have appeared to influence the work reported in this paper.
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Abstract
Many promoting factors of cardiometabolic disease are commonplace in Police Academy (POLAC), such as prolonged sitting, forgoing sleep, poor stress management, and others. The research aimed to establish the cardiometabolic profile of some POLAC staff. Voluntary staff members participated in the study. The participants fasted for at least ten hours. Plasma capillary blood parameters (glucose, haemoglobin, and total cholesterol), blood pressure (BP) and anthropometry (waist and hip circumference, and height and weight) were determined. The Body mass index (BMI) and waist-to-hip circumference ratios were calculated using the appropriate formula. The participants were divided into five groups according to age range (Group1 = 40-45, Group2 = 46-50, Group3 = 51-55, Group4 = 56-60, and Group5 = 61-65). The results showed the presence of high glucose concentrations (glucose > 6.8mmol/L) in all groups, high haemoglobin concentrations (haemoglobin > 17.2g/dl) in two groups (1 and 2), high total cholesterol concentrations (total cholesterol > 240 mg/dl) in four groups (1, 2, 3, and 5), and high BMI (BMI > 24.9 kg/m2), high BP (BP ≥ 140/90 mmHg) and high waist-to-hip ratio (values > 1) in all groups. The mean glucose, BP and anthropometric measurements were elevated across all groups. Individually, there were no significant differences among the groups. High glucose concentrations, BP and anthropometric values in all groups reflect that glucose concentration impacts body anthropometry alongside BP and anthropometry reflect glucose status. The high total cholesterol concentrations in the four groups rather than all groups showed glucose may trigger an increase in total cholesterol, and other factors may be involved. Haemoglobin concentration is less affected by glucose concentration. Changes in these parameters reflect cardiometabolic health conditions.
Abstract Keywords
Cardiometabilic condition, anthropometrics, glucose, haemoglobin and cholesterol.
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Editor-in-Chief
This work is licensed under the
Creative Commons Attribution 4.0
License.(CC BY-NC 4.0).